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Effects of Resistance Training Following Bone Marrow Stem Cell Transplantation on Cardiac Oxidative Stress and Left Ventricular Function in a Rat Model of Myocardial Infarction
Hossein Mahdian1 , Seyed Abdollah Hashemvarzi2 , Kamal Ranjbar3
1- Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran.
2- Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran. , Hashemvarzi_tkd@yahoo.com
3- Department of Physical Education and Sport Science, BA.C, Islamic Azad University, Bandar Abbas, Iran.
Abstract:   (613 Views)
Background and objectives: This study aimed to evaluate the effects of resistance training following bone marrow stem cell transplantation, a regenerative approach targeting damaged cardiac tissue, on myocardial oxidative stress markers and left ventricular function in a rat model of myocardial infarction (MI).
Methods: Sixty male Wistar rats (7–8 weeks old) were randomly assigned to six experimental groups (n=10 per group): healthy control, MI control, sham, stem cell, exercise, and exercise + stem cell. MI was induced by permanent ligation of the left anterior descending coronary artery. Stem cells (1×10⁶) were injected via the tail vein. Resistance training protocol consisted of climbing sessions performed five days per week for six weeks. Each session included three sets of five repetitions, with a one-minute rest interval between sets. Oxidative stress markers (CAT and MDA) were analyzed biochemically, and left ventricular function was assessed by echocardiography. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: MDA levels were significantly increased and CAT levels decreased in the MI group compared to controls. Resistance training and combined therapy significantly reduced MDA levels; however, CAT changes were not statistically significant. Cardiac output and ejection fraction were significantly improved in the intervention groups compared to the MI group.
Conclusion: Six weeks of resistance training after bone marrow stem cell transplantation effectively reduced oxidative stress and improved left ventricular function in MI rats. This combined approach may serve as a promising therapeutic strategy for myocardial infarction recovery.
 
Keywords: resistance training, stem cell, oxidative stress, left ventricular function, myocardial infarction
Full-Text [PDF 485 kb]   (185 Downloads)    
Research Article: Research Article | Subject: Sport Physiology
Received: 2025/09/25 | Accepted: 2026/01/28
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