Back to the articles list | Back to browse issues page

XML Print

Clinicopathological Features and Survival Outcomes of Pediatric Mediastinal Tumors: A 10-Year Retrospective Study
Mahlagha Zahedi1 , Sahar Abasinia2
1- Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , mahlaghazahedi@gmail.com
2- General physician,Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (267 Views)

Background and objectives: Primary mediastinal masses account for 3% of all chest tumors. Given their varied clinical presentations and the need for accurate diagnosis, this study investigates the clinicopathological features and survival outcomes of children with primary mediastinal masses admitted to Shahid Sadoughi Hospital, Yazd, Iran, from 2011 to 2021.
Materials and Methods: In this descriptive cross-sectional study, 17 children under 18 years with primary mediastinal masses were examined using census sampling. Data were collected via a checklist covering age, sex, tumor location, symptoms, tumor type, treatment received, and malignancy status. Prognosis and survival were tracked. Statistical analysis was performed using SPSS 22, employing Kaplan-Meier and Log-Rank tests for survival assessment.
Results: Among the 17 patients, 12 (70.6%) were girls and 5 (29.4%) boys. Five patients (29.4%) died during follow-up. Nine tumors (53%) were benign and eight (47%) malignant. Ganglioneuroma was the most frequent tumor (29.4%). Survival analysis revealed no statistically significant association between survival and surgery (P=0.222), malignancy status (P=0.158), neural origin (P=0.666), chemotherapy (P=0.057), radiotherapy (P=0.752), tumor location (P=0.661), sex (P=0.670), or age (P=0.877).
Conclusion: The study suggests that the distribution of histological types of primary mediastinal masses in children is influenced by anatomical location. However, factors such as age, sex, treatment type, and tumor location do not significantly affect survival outcomes in these patients.

 

Keywords: Pediatric mediastinal tumors, Clinicopathological features, Survival analysis, Histological subtypes, Iran
Full-Text [PDF 243 kb]   (124 Downloads)    
Research Article: Research Article | Subject: Pathology
Received: 2025/04/18 | Accepted: 2025/10/28
References
1. Cook MS, Weinhaus AJ. Anatomy of the thoracic wall, pulmonary cavities, and mediastinum. Handbook of Cardiac Anatomy, Physiology, and Devices. 2015:35-60. [View at Publisher] [DOI] [Google Scholar]
2. Mandal AP, Dutta S, Das M, Saha R, Das TK. Mediastinal tumors: a clinicopathological study with special reference to immunohistochemistry. IOSR J Dent Med Sci. 2020;19(6):10-8. [View at Publisher] [DOI] [PMCID]
3. Biko DM, Lichtenberger III JP, Rapp JB, Khwaja A, Huppmann AR, Chung EM. Mediastinal masses in children: radiologic-pathologic correlation. RadioGraphics. 2021;41(4):1186-207. [View at Publisher] [DOI] [PMID] [Google Scholar]
4. Ghigna M-R, de Montpreville VT. Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach. Eur Respir Rev. 2021;30(162):200309. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Tejaswi P, Prabhala S, Deshpande AK. Lipoma: a ubiquitous tumor at uncommon locations. Int J Clin Diagn Pathol. 2020;3(1):34-8. [View at Publisher] [DOI] [Google Scholar]
6. Davis Jr RD, Oldham Jr HN, Sabiston Jr DC. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 1987;44(3):229-37. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Whooley BP, Urshel JD, Antkowiak JG, Takita H. Primary tumors of mediastinum. J Surg Oncol. 1999;70(2):95-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Liu T, Al-Kzaye LFY, Xie X, Fan H, Sarsam SN, Nakazawa Y,et al. Mediastinal lesions across the age spectrum: a clinicopathological comparison between pediatric and adult patients. Oncotarget. 2017;8(35):59845. [View at Publisher] [DOI] [PMID] [Google Scholar]
9. Seth R. Clinicopathological analysis of malignant mediastinal masses in children. J Cancer Res Ther. 2017;13. [View at Publisher] [DOI] [Google Scholar]
10. Ahmadi J, Kalantari M, Raeis Alsadat, Mehrabi V, Nahvi H. A review of mediastinal tumors in children. Tehran Univ Med J. 2004;62(4):345-50. [View at Publisher] [Google Scholar]
11. Verma S, Kalra K, Rastogi S, Sidhu HS. Clinical approach to childhood mediastinal tumors and management. Mediastinum. 2020;4:21 [View at Publisher] [DOI] [PMID] [Google Scholar]
12. Choe J, Lee SM, Ahn Y, Kim CH, Seo JB, Lee HY. Characteristics and outcomes of anterior mediastinal cystic lesions diagnosed on chest MRI: implications for management of cystic lesions. Insights Imaging. 2022;13(1):136. [View at Publisher] [DOI] [PMID] [Google Scholar]
Add your comments about this article : Your username or Email:
CAPTCHA
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.