fa تحقيقي Original Paper <div> <p><strong>ABSTRACT</strong></p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objective:</strong> Nutritional factors and activation of inflammatory pathways are thought to be involved in pathogenesis of preeclampsia in pregnant women. The present study aimed to compare the serum levels of vitamin D and interleukin-6 in healthy pregnant women with those of preeclampsia ones.</p> <p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Methods:</strong> This case-control study was performed on 120 healthy pregnant women and 120 women with preeclampsia referred to Imam Reza Hospital in Kermanshah. The serum levels of vitamin D and IL-6 were measured by ELISA method. The data was analyzed by SPSS software (version 20) using independent t-test, the P-value of <0.05 was considered as statistically significant.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results:</strong> There was no statistically significant difference between the mean level of vitamin D in the patients (37.64 &plusmn; 29.50 ng/ml) and the controls (40.06 &plusmn; 33.20 ng/ml). the serum level of IL-6 in patients with preeclampsia (21.71 &plusmn; 32.24 pg/ml) was significantly higher compared to that of&nbsp; control group (15.04 &plusmn; 28.6 pg/ml) (P <0.001).</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Conclusion:</strong> Based on the findings of this study, inflammatory factors and cytokines such as IL-6 can be considered as risk factor for preeclampsia. However, more studies with larger sample sizes are required to further evaluate the association of vitamin D levels and risk of preeclampsia.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Keywords:</strong> Pregnancy, <a href="https://www.ncbi.nlm.nih.gov/mesh/68011225">Pre-Eclampsia</a>, Vitamin D, <a href="http://www.ncbi.nlm.nih.gov/mesh/68015850">Interleukin-6</a><em>.</em></p> </div> Pregnancy, Pre-Eclampsia, Vitamin D, Interleukin-6. 12 17 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-409&slc_lang=fa&sid=1 Negin Rezavand 100319475328460011049 100319475328460011049 No Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Asad Vaisi-Raygani avaisiraygani@gmail.com 100319475328460011050 100319475328460011050 Yes Professor of Clinical Biochemistry, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Firozeh Vaisi 100319475328460011051 100319475328460011051 No Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Maryam Zangneh 100319475328460011052 100319475328460011052 No Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Azin Hoshiar 100319475328460011053 100319475328460011053 No Department of Obstetrics and Gynecology, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Fariborz Bahrehmand 100319475328460011054 100319475328460011054 No Department of Clinical Biochemistry, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Amir Kiani 100319475328460011055 100319475328460011055 No Department of Pharmacology and Toxicology, Kermanshah University of Medical Sciences, Kermanshah, Iran Gholamabass Dinarvand 100319475328460011056 100319475328460011056 No Department of Biochemistry, Faculty member of Abadan School of Medical Sciences, Abadan, Iran