Medical Laboratory Journal

en Effects of Resistance Training Following Bone Marrow Stem Cell Transplantation on Cardiac Oxidative Stress and Left Ventricular Function in a Rat Model of Myocardial Infarction فیزیولوژی ورزشی Sport Physiology Research Article Research Article Background and objectives: This study aimed to evaluate the effects of resistance training following bone marrow stem cell transplantation, a regenerative approach targeting damaged cardiac tissue, on myocardial oxidative stress markers and left ventricular function in a rat model of myocardial infarction (MI). Methods: Sixty male Wistar rats (7–8 weeks old) were randomly assigned to six experimental groups (n=10 per group): healthy control, MI control, sham, stem cell, exercise, and exercise + stem cell. MI was induced by permanent ligation of the left anterior descending coronary artery. Stem cells (1×10⁶) were injected via the tail vein. Resistance training protocol consisted of climbing sessions performed five days per week for six weeks. Each session included three sets of five repetitions, with a one-minute rest interval between sets. Oxidative stress markers (CAT and MDA) were analyzed biochemically, and left ventricular function was assessed by echocardiography. Data were analyzed using one-way ANOVA and Tukey’s post hoc test. Results: MDA levels were significantly increased and CAT levels decreased in the MI group compared to controls. Resistance training and combined therapy significantly reduced MDA levels; however, CAT changes were not statistically significant. Cardiac output and ejection fraction were significantly improved in the intervention groups compared to the MI group. Conclusion: Six weeks of resistance training after bone marrow stem cell transplantation effectively reduced oxidative stress and improved left ventricular function in MI rats. This combined approach may serve as a promising therapeutic strategy for myocardial infarction recovery.   resistance training, stem cell, oxidative stress, left ventricular function, myocardial infarction 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-404-3&slc_lang=en&sid=1 Hossein Mahdian hossein.mahdian@gmail.com 100319475328460032397 100319475328460032397 No Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran. Seyed Abdollah Hashemvarzi Hashemvarzi_tkd@yahoo.com 100319475328460032398 100319475328460032398 Yes Department of Physical Education and Sport Science, Sar.C, Islamic Azad University, Sari, Iran. Kamal Ranjbar kamal_ranjbar2010@yahoo.com 100319475328460032399 100319475328460032399 No Department of Physical Education and Sport Science, BA.C, Islamic Azad University, Bandar Abbas, Iran.