Medical Laboratory Journal

en Association Between Lipid Metabolism Markers and Gastric Cancer Stage and Grade: A Focus on ApoB بیوشیمی Biochemistry تحقيقي Original Paper Background and Objectives: Gastric cancer (GC), particularly adenocarcinoma, remains a global health burden with high mortality due to late-stage diagnosis and limited reliable biomarkers for disease monitoring. Lipid metabolism plays a crucial role in tumor biology, and serum lipid-related markers, including apolipoproteins, have been suggested as potential non-invasive indicators of tumor progression. This study aimed to evaluate the association between serum lipid profiles and tumor stage and histological grade in patients with gastric adenocarcinoma. Methods: Fifty patients diagnosed with gastric adenocarcinoma were enrolled. Serum levels of total cholesterol, triglycerides, HDL-C, LDL-C, ApoA1, and ApoB were measured. Patients were categorized into early (stages I–II) and advanced (stages III–IV) tumor stages, as well as into moderately differentiated versus poorly differentiated grades. The Shapiro-Wilk test was used to assess data normality. Parametric and non-parametric tests were applied accordingly. A p-value < 0.05 was considered statistically significant. Results: ApoB was the only parameter showing a significant association with tumor stage. Patients with advanced-stage GC had significantly lower mean ApoB levels compared to those in early stages (52.4 ± 2.6 vs. 63.4 ± 5.2 mg/dl, p = 0.042). No statistically significant differences were observed in ApoA1, HDL-C, total cholesterol, triglycerides, LDL-C, or VLDL, for either tumor stage or histological grade. Conclusion: ApoB levels appear to decline with advancing tumor stage in gastric adenocarcinoma, suggesting a potential role as a marker to evaluate disease burden. While no association was found with tumor grade, further validation in larger prospective studies incorporating metabolic and inflammatory covariates is warranted. Adenocarcinoma, Stomach, Apolipoprotein B, Lipid Metabolism, Neoplasm Staging, Neoplasm Grading 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1534-1&slc_lang=en&sid=1 Amir Asghary asghary_a@umsu.ac.ir 100319475328460032400 100319475328460032400 No Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran. Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. 0000-0003-0344-3870 Marie saghaeian Jazi marie.saghaeian@goums.ac.ir 100319475328460032401 100319475328460032401 No Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran Seyed Mostafa Mir mostafamir1987@gmail.com 100319475328460032402 100319475328460032402 No Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Abbas Doulani a.doulani@alzahra.ac.ir 100319475328460032403 100319475328460032403 No Department of Information Science, Faculty of Education and Psychology, Alzahra University, Tehran, Iran Hamid Reza Joshaghani joshaghani@goums.ac.ir 100319475328460032404 100319475328460032404 Yes Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran. 0000-0003-3392-304X