en عصاره های گیاهی Herbals تحقيقي Original Paper <span style="font-size:12pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Background</b>: Mercury chloride is a well-established toxicant known to induce hematological alterations, including oxidative hemolysis, anemia, and thrombocytopenia. Medicinal plants with antioxidant properties have been explored as potential protective agents against toxicant-induced damage. <i>Anthocleista djalonensis</i>, widely used in traditional medicine, has been reported to possess bioactive compounds with therapeutic potential. This study aimed to investigate the role of <i>Anthocleista djalonensis</i> in mitigating mercury chloride-induced hematological alterations.<span style="background:yellow"></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b><span style="background:yellow">Methods</span></b><span style="background:yellow">: This experimental randomised controlled animal study was kind of weirdly done, with thirty-six adult Wistar rats, randomly assigned into six groups, (n=6 each). Group A was basically the control, Group B got only 2 mg/kg of mercury chloride , just that. Groups C and D were given mercury chloride alongside 150 mg/kg and 300 mg/kg of <i>Anthocleista djalonensis</i> extract, respectively , while Groups E and F received just <i>A. djalonensis</i> at doses 150 mg/kg and 300 mg/kg. The extract was freeze dried, and then the haematological parameters were checked using an automated haematology analyser. For the statistics, it was handled with one-way ANOVA, and the significance cut off was p < 0.05.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:200%"><span new="" roman="" style="font-family:" times=""><b>Results</b>: Mercury chloride exposure significantly reduced red blood cell count, hemoglobin concentration, and platelet levels, indicating hematotoxicity. Co-administration with <i>A. djalonensis</i>, particularly at 150 mg/kg, significantly improved these hematological indices, suggesting a protective effect. The plant extracts also enhanced mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, indicating potential erythropoietic support.</span></span></span> Mercury chloride, Hematotoxicity, Anthocleista djalonensis, Antioxidant, Hematological parameters. 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1898-1&slc_lang=en&sid=1 Joseph Raymond Enoghase joseph.enoghase@bmedsci.uniben.edu 100319475328460032424 0009-0002-4603-6853 Yes University of Benin Silvanus Olu Innih silvanus.innih@uniben.edu 100319475328460032425 100319475328460032425 No University of Benin