fa مروري Review Article <div><strong>ABSTRACT</strong><br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Colorectal cancer remains a leading cause of morbidity and mortality worldwide. Most colorectal cancers begin as a growth of tissue called a polyp, some types of which can change into cancer over the course of several years. Angiogenesis, the formation of new blood vessels, is known to play a key role in the initiation, growth and progression of polyp and colorectal cancer. In this review, we discuss the mechanisms involved in colorectal cancer and polyp angiogenesis.</div> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Keywords:</strong> <a href="https://www.ncbi.nlm.nih.gov/mesh/68015179">Colorectal Neoplasms</a>, Polyps, Angiogenesis Colorectal Neoplasms, Polyps, Angiogenesis 1 6 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-528&slc_lang=fa&sid=1 Hamid Asadzadeh Aghdaei 100319475328460014484 100319475328460014484 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zahra Pezeshkian 100319475328460014485 100319475328460014485 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Meghdad Abdollahpour-Alitappeh 100319475328460014486 100319475328460014486 No Larestan University of Medical Sciences, Larestan, Iran Ehsan Nazemalhosseini Mojarad ehsanmojarad@gmail.com 100319475328460014487 100319475328460014487 Yes Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Reza Zali 100319475328460014488 100319475328460014488 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran