Ommolbanin Younesian, Behnaz Khodabakhshi, Sara Hosseinzadeh, Seyedeh Somayeh Hosseini Alarzi, Samareh Younesian, Mojtaba Pourmomen, Mana Zakeri, Ali Hosseini, Professor Hamidreza Joshaghani,
Volume 17, Issue 5 (9-2023)
Abstract
Background: Although public health interventions have slowed the spread of SARS CoV 2 infections, the worldwide pandemic of COVID 19 is progressing. Thus, effective and safe vaccination against SARS CoV 2 is an important tool for controlling the COVID 19 pandemic. Now in the early stages of COVID 19 vaccination, vaccinated individuals are interested in using antibody tests to confirm vaccination success and estimate the time of protection. Here, we assessed anti spike IgG responses in the general population 2 weeks after the second dose of the Sputnik V vaccine.
Methods: This study included blood samples of 67 individuals without a previous SARS CoV 2 infection taken 14 days after the second dose of the Sputnik V vaccine. Anti spike IgG responses were assessed with an enzyme linked immunosorbent assay (ELISA).
Results: Anti spike IgG was detected in 55 (82.1%) of 67 samples 14 days after the second dose of the Sputnik V vaccine. Antibody levels were significantly lower in males than in females, and 9 (75%) of 12 seronegative individuals were males.
Conclusion: Vaccination resulted in detectable anti spike IgG in 82.1% of individuals, and gender may be an important factor in the humoral response.
Neema Tiwari , Richa Sharma , Prachi Saxena ,
Volume 19, Issue 4 (7-2025)
Abstract
Background: Nucleated red blood cells (nRBCs) are immature erythrocytes whose production is thought to be driven primarily by the interplay of hypoxia and erythropoietin synthesis. Neonatal sepsis is classified as early-onset (occurring within the first 24 hours of life) or late-onset (Occurring after 48-72 hours). The aim of this study was to analyze the cause for the presence of nRBCs in the peripheral blood of neonates sent for routine workup in the Hematology Laboratory of the Department of Pathology, SMSR, Sharda University.
Methods: Retrospective analysis of 27 complete blood counts and peripheral blood smears of neonates was conducted over one month. Smears had been prepared and stored for examination, and reports had been dispatched. Clinical details (As available from clinicians), parameters for neonatal sepsis (NLR, PLR, IG), platelet counts, and nRBC counts were recorded and tabulated. For result tabulation, neonatal samples were divided into two groups: 0-1 day and 2-30 days.
Results: The neonates included 17 males and 9 females. Assessment of NLR, PLR, and IG indicated higher values in the 2-30-day group compared to the 0-1-day group. Moreover, nRBCs were also elevated in the 2-30-day group.
Conclusion: The presence of nRBCs in peripheral blood smears is an important indicator of neonatal stress, including sepsis, jaundice, and hypoxic sepsis.
