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Showing 2 results for Nontuberculous Mycobacteria
An Update on the Prevalence of Nontuberculous Mycobacteria in Clinical Samples in Iran during 2000-2022: A Systematic Review and Meta-Analysis
Fahimeh Firoozeh, Arezoo Firoozeh, Abbas Salmani,
Volume 17, Issue 3 (5-2023)
Abstract
Background and objectives: Nontuberculous mycobacteria (NTM) are isolated from domestic and animal products as well as man-made systems such as medical devices, drinking water systems, water tanks, and shower streams.  This study aimed to investigate the prevalence of NTM in clinical samples in Iran during 2000-2022.
Methods: Published studies addressing the prevalence of NTM in clinical samples in Iran were reviewed according to the Preferred Reporting Items for Meta-Analyses and Systematic Reviews protocol.  Original articles in Persian and English published between January 2000 and 2022 in databases such as Scopus, PubMed, Web of Science, Google Scholar, and Iranian databases were included. The prevalence of NTM at 95% confidence interval (CI) was calculated by comprehensive meta-analysis.
Results: Overall, 26 studies were included in the review. The combined prevalence of NTM in positive mycobacterial cultures was 4.5% (95% Cl: 3.1-6.5). Mycobacterium simiae [35.8% (95% CI 16.4-44.4)], Mycobacterium intracellulare [19% (95% CI 8.7-28.3)], and Mycobacterium kansasii [13.4% (95% CI 7.3-24.3)] were the most common slowly growing species, while Mycobacterium fortuitum [24.6% (95% CI 12.9-46.7)], Mycobacterium terrae [18.5 % (95% CI 11.5-29.2)], and Mycobacterium gastri [15.9% (95% CI6.0-41.2)] were the most prevalent rapidly growing mycobacteria. 
Conclusion:  In summary, our findings indicate a relatively high combined prevalence of NTM in clinical samples in Iran.  Some of these species such as M. simiae can have clinical and radiologic manifestations similar to those of TB and are resistant to anti-TB drugs. Therefore, standardizing the use of molecular methods for the detection of NTM seems necessary.


 

Pacemaker pocket infection due to Mycobacterium abscessus subspecies abscessus: A Case Report and Literature Review
Maanasa Bhaskar Manalikandy, Ankita Mohanty , Noyal Maria Joseph , Raja Jaisundar Selvaraj, Sujatha Sistla ,
Volume 19, Issue 6 (11-2025)
Abstract
Background: Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium that can cause various infections in humans. The identification of nontuberculous mycobacteria remains a challenge to date due to the availability of limited resources. There have been reports of device-related infections caused by these bacteria. Improper care of cardiac implants can give rise to infections that need to be identified promptly. This report emphasizes the need for early and prompt diagnosis of non-tuberculous mycobacterial infections.
Case Report: Here, we present a case of a 69-year-old man who presented with an atrioventricular block and therefore underwent pacemaker implantation. The implant became infected with Mycobacterium abscessus, which resolved after appropriate treatment and pacemaker removal.
Conclusion: Non-tuberculous mycobacteria must be promptly identified and treated for the appropriate duration to prevent complications associated with them.

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