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Showing 3 results for Hemoglobins
Changes in Some Hematology Parameters in poisoning with Rice Tablet (Aluminum Phosphide)
Farshid Fayyaz ,
Volume 9, Issue 4 (10-2015)
Abstract

Abstract

     Background and Objective: Aluminum Phosphide (ALP) is a solid non-organic phosphide with dark gray or dark yellow crystals. It reacts with stomach acid after ingestion and causes phosphine gas to be released. It is thought that phosphine causes toxicity from enzymatic interference and may even lead to cell death. This study aimed to investigate the effects of poisoning with rice tablet on levels of platelets, hemoglobin, white blood cells.

     Methods: The clinical records of 67 cases of acute oral toxicity with aluminum phosphide admitted to Baharloo hospital and 28 forensic autopsy cases in Kahrizak forensic research center were studied. Recorded information included vital signs, demographic characteristics, numerous laboratory and clinical findings, complications and all pathologic findings.

      Results: All patients had received standard symptomatic and supportive treatments. Among the tested subjects, 30 of 67 patients (44.8%) were male. The mean hemoglobin level of recovered and deceased individuals was 12.26 and 11.72 g/dl, respectively. There was a significant relationship between patients’ WBC counts and mortality where the mean level of WBC in the deceased  was more than that of the recovered (P=0.001). Mean SBP in the deceased and the recovered individuals was 79.67 ± 12.89 and 102.46 ± 22.57 mmHg, respectively.

      Conclusion: Consumption of rice tablets results in blood pressure alteration, hemoglobin levels, platelets and leukocyte count. Tracking these alterations can reduce the side effects and mortality rate in the cases of rice tablet poisoning.

     Keywords: Aluminum Phosphide, White Blood Cells, Hemoglobins, Blood Pressure, Patients


The effect of methotrexate on blood, liver, and renal parameters in patients with rheumatoid arthritis
Bizav Rasheed , Beri Tawfeq,
Volume 18, Issue 6 (11-2024)
Abstract
Background: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. The disease may also affect other parts of the body, including the skin, eyes, lungs, heart, nerves, and blood. This study aimed to evaluate the effect of methotrexate on blood, liver, and renal parameters in patients with RA.
Methods: A six-month cross-sectional study was carried out on 60 consecutive patients aged 19-70 years diagnosed with RA on methotrexate treatment (10 mg) orally per week. A questionnaire was taken from participants, and laboratory tests were done on renal and liver function and complete blood count (CBC), erythrocyte sedimentation rate (ESR), glutamic oxaloacetic transaminase (SGOT or AST), glutamate pyruvate transaminase (SGPT or ALT), Creatinine, C-reactive protein (CRP), and rheumatoid factor (RF) as a follow-up to drug intake.
Results: At the end of sample collection, participants ranged in age from 19 to 70 years, with a female-to-male ratio of 1.5:1. Significant differences in platelet (PLT) levels were observed only between days 1 and 14 of the treatment (p <0.05). Similarly, SGPT levels showed significant variation between days 1 and 30 of the treatment (p <0.05). Additionally, RF levels exhibited significant differences between days 1 and 14 (p <0.01) and between days 1 and 30 of the treatment (p <0.04).
Conclusion: The recommended medication for all kinds of patients with RA is methotrexate, which has had a notable impact on blood, liver, and kidney parameters. These characteristics can serve as indicators for monitoring the medication’s effectiveness, safety, and patient follow-up.
 

JAK2 mutation, a potential cause of increasing Hemoglobin levels in symptomatic aged women
Zeinab Siahmargoie , Mohammad Taher Hojjati , Hadi Bazzazi , Khodaberdi Kalavi , Mana Zakeri , Hadi Joshaghani ,
Volume 19, Issue 2 (3-2025)
Abstract
Background: Polycythemia Vera (PV) is a myeloproliferative neoplasm (MPN) characterized by the overactivity of erythroid progenitors, leading to excessive red blood cell (RBC) production. More than 90% of PV cases harbor a Janus kinase 2 (JAK2) gene mutation. This study aimed to assess the prevalence of JAK2 mutations in individuals with elevated hemoglobin (Hb) levels referred to the laboratory by physicians.
Methods: In this descriptive cross-sectional study, genomic DNA from 72 patients was analyzed for JAK2 mutations using a TaqMan-specific probe.
Results: Of the 72 patients, 24 (33.3%) were women and 48 (66.6%) were men. JAK2 mutations were detected in 33 cases (45.5%), while 39 (54.2%) were negative. Notably, 15 of 24 female patients (62.5%) tested positive for the JAK2 mutation, compared to 18 of 48 male patients (37.5%).
Conclusion: Our findings suggest that screening for JAK2 mutations is particularly important in women with above-normal Hb levels.

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