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Showing 2 results for Eftekhari
Exogenous Lung Surfactant Decreases Interleukin-8 Production and Increases Leukocytes Population and Total Immunoglobulins in Rabbits
Sepideh Yamini, Zohre Eftekhari, Mohammad Reza Mokhber Dezfouli, Babak Beikzadeh, Parvane Mehrbod,
Volume 13, Issue 6 (Nov-Dec 2019)
Abstract
ABSTRACT
           Background and Objectives: Exogenous lung surfactant (ELS) obtained from extraction of bronchoalveolar lavage fluid, is prescribed in some respiratory disorders, which could affect production of lung-related cytokines. Interleukin-8 (IL-8) is a major cytokine that could affect severity of lung diseases. In this study, we investigate the possible impact of ELS on IL-8 expression, hematological parameters and IgG and IgM levels in rabbits.
           Methods: ELS solution obtained from fresh calf’s lung bronchoalveolar lavage was infused into the lungs of five rabbits via tracheal tube. Blood samples were collected before and after ELS treatment for 30 days.
           Results: Serum IL-8 levels decreased over time following ELS administration. IL-8 expression also decreased after exposure to ELS, but leukocytes count increased significantly 24, 48 and 72 hours after ELS therapy compared to baseline values (P<0.05). IgM level increased significantly 72 hours after the ELS therapy and returned to normal range at the end of study.
           Conclusion: Our findings suggest that ELS could down-regulate IL-8 expression in mononuclear cells while increasing leukocytes population and total immunoglobulins level, which can trigger immune responses without lung damage. However, further studies should be performed to confirm the regulatory effects of ELS on inflammatory responses in lung diseases.
           Keywords: Exogenous lung surfactant, IL-8, Immunoglobulins.

Prevalence and antibiotic resistance patterns of bacterial infections in dermatology inpatients: A cross-sectional study
Hadi Sedigh Ebrahim-Saraei, Tofigh Yaghoubi , Zeynab Fathalizadeh , Masoumeh Pourmohammadi , Hojat Eftekhari ,
Volume 20, Issue 4 (9-2026)
Abstract
Background: Nosocomial infections are among the most concerning issues affecting hospitalized patients. The present study investigated the frequency of bacterial infections and their antibiotic resistance patterns among patients hospitalized in the dermatology ward.
Methods: This cross-sectional study was conducted among patients admitted to the dermatology ward at Razi Hospital, Rasht, Iran, between 2018 and 2022. The demographic data and clinical characteristics of the 34 patients with bacterial infections were recorded and analyzed. Bacterial isolates were obtained from skin and soft tissue, urinary tract, or bloodstream infections, and the patients' clinical findings and outcomes were recorded.
Results: Thirty-four patients had positive bacterial culture results. The mean age of the patients was 53.56±17.14 years, and 61.8% were female. The urinary tract was the most frequent site of infection. Staphylococcus epidermidis (S. epidermidis) and Klebsiella spp. were the most prevalent isolates. Klebsiella spp. and Escherichia coli (E. coli) were more common in patients aged <56 years and ≥56 years, respectively, and in those hospitalized for ≥13 days and <13 days, respectively. Antibiotic resistance was high among S. epidermidis and Pseudomonas aeruginosa (P. aeruginosa) isolates, both of which showed resistance to all antibiotics.
Conclusion: This study revealed significant patterns of bacterial infection and antibiotic resistance among patients in the dermatology ward. E. coli and Klebsiella spp. predominated in urinary tract infections, whereas skin and soft tissue infections exhibited a more diverse profile.

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