en آسيب شناسي Pathology تحقيقي Original Paper <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> A frozen section is a rapid diagnostic procedure performed on tissue obtained intraoperatively that helps the operating surgeon make immediate decisions during surgery, primarily by distinguishing between benign and malignant neoplasms. It plays a significant role in guiding intraoperative and perioperative patient management and reduces the need for re-operation.<br> <b>Methods:</b> The present study aimed to evaluate the diagnostic accuracy, sensitivity, and specificity of frozen section examination. An analysis of 49 frozen sections was conducted in the Pathology Department from September 2022 to May 2024. The frozen section diagnoses were compared with those obtained from routine paraffin sections. The results were classified as concordant or discordant. Diagnostic accuracy, sensitivity, and specificity were calculated.<br> <b>Results:</b> Of the 49 cases, the diagnosis was concordant with routine histopathology in 47 cases, whereas 02 cases were discordant. The overall diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 95.92%, 96%, 95.43% ,96%, and 95.43%, respectively. The discordance rate was 4.08%.<br> <b>Conclusion</b>: Frozen section examination is a reliable, accurate, and rapid technique for intraoperative consultation. Several factors can affect the accuracy of frozen section diagnosis, including sampling, technical, and interpretation errors.</span></span></div> Frozen Sections, Diagnostic Accuracy, Concordant, Discordant 0 0 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1356-2&slc_lang=en&sid=1 Sarangi Wankhade sarangiwankhade90@gmail.com 0009-0004-9135-3924 No Department of Pathology, TATA Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) Kharghar, Navi Mumbai, India Smita Bhide smitapbhide@gmail.com 0000-0003-4221-6259 Yes Department of Pathology, MIMER Medical College, Talegaon Dabhade, Pune, India