Fahimeh Hosseinabadi, Tayebeh Faraji, Mahdi Malmir,
Volume 9, Issue 4 (12-2021)
Abstract
Background and Objective: Quercetin is a polyphenolic flavonoid compound with a potent antioxidant impact, proposed to make a drastic contribution in treating male infertility. The current systematic review aimed to provide an overview of previous studies about quercetin's impact on male infertility.
Material and Methods: Electronic search with MeSH words including Quercetin, Infertility, Sperm, Testicular tissue, and Sex hormones was accomplished in databases Web of Science, Scopus, Science Direct, Wiley, NCBI, and Google Scholar. Finally, 296 articles were recognized during the primary search. A total of 144 papers,passing the analysis stage containing Identification, Screening, and Eligibility were selected for assessment.
Results: Quercetin prevents damage to the testicular germinal epithelium and facilitates the spermatogenesis process by strengthening the antioxidant system, reducing lipid peroxidation and oxidative stress, preventing the expression of pro-apoptotic genes, increasing testosterone and gonadotropins.
Conclusion: In conclusion, the present review showed that quercetin by its antioxidant impacts, can counteract various toxins that induce oxidative stress in the male reproductive system.
Mojdeh Khajehlandi, Lotfali Bolboli,
Volume 12, Issue 2 (10-2024)
Abstract
Background: Mitochondrial function is an integral part of glucose-stimulated insulin secretion in pancreatic β-cells and is a hallmark feature of cardiovascular disease. It may contribute to the pathophysiology of diabetic cardiomyopathy and atherosclerosis. This study aimed to investigate the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), combined with quercetin supplementation (eight weeks), on mitochondrial gene expression in the diabetic heart.
Methods: In this study, 35 adult male rats were equally divided into seven groups (n=5): healthy sedentary, diabetic sedentary, diabetic quercetin sedentary, diabetic HIIT (DHIIT), diabetic MICT (DMICT), DHIIT with quercetin, and DMICT with quercetin. The rats were fed a high-fat diet for eight weeks and subsequently treated with a single low dose of streptozotocin to create a model of type 2 diabetes mellitus (T2DM). Eight weeks (five times a week) of HIIT and MICT, with and without quercetin, were conducted for the training groups, and quercetin was injected over eight weeks at a dose of 15 mg/kg.
Results: Eight weeks of quercetin supplementation, HIIT, and MICT, with and without quercetin, significantly decreased blood glucose levels (P=0.001). Eight weeks of HIIT and MICT training increased nuclear respiratory factor-2 (NRF2) (P=0.001) and adipose triglyceride lipase (ATGL) (P=0.001) expression and decreased perilipin 2 (PLIN2) gene expression (P=0.001).
Conclusion: The training groups alone improved the gene expression of NRF2, ATGL, and PLIN2. Both training protocols, combined with quercetin, controlled blood glucose levels and improved antioxidant capacity. Thus, the reduction in blood glucose through quercetin supplementation appears to be a promising approach for managing T2DM.
