Search published articles


Showing 2 results for Infertility

Seyed Mostafa Ghavami, Nahideh Gharehaghaji,
Volume 4, Issue 1 (5-2016)
Abstract

Background & Objectives: In spite of rapid development and arrival of newer medical imaging modalities such as computed tomography and magnetic resonance imaging, hysterosalpingography (HSG) has a great role among imaging techniques because of its enormous advantages. HSG is the standard screening test for the diagnosis of tubal infertility and can provide useful information about the uterine cavity. The aim of this study was to demonstrate the value of HSG in the evaluation of infertility and to diagnose the tubo-uterine causes of infertility in Tabriz.

Methods: In current study, 1260 patients were investigated for infertility by HSG, patients of both primary and secondary infertility were included except those who have history of acute pelvic infection and allergy to contrast media. This study was conducted at Day Medical Imaging Center in Tabriz-IRAN.

Results: HSG outlined normal uterus cavity, normal tube bilaterally with peritoneal spill in 1045 patients (82.94%) and 215 cases (17.06%) were detected with abnormalities. Among these patients, 78 cases (36.28%) detected with normal uterine shape and block of one tube, 32 (14.88%) patients shows both tubal blockages with normal uterus. There was bicurnate uterus in one patient (0.47%) with blockage of both tubes

Conclusion: The most common abnormal finding was normal uterus cavity with block of one or both tubes. Prevention of the pelvic inflammatory diseases, on time diagnosis and treatment of genital infectious, avoiding unnecessary pelvic surgeries, healthcare improvement and increasing the knowledge of society are the important decreasing factors in the women infertility.


Telnaz Bahrami, Masoud Maleki,
Volume 7, Issue 2 (7-2019)
Abstract

Infertility is a disorder of the reproductive system, which often occurs after one year of regular unprotected intercourse with the aim of pregnancy. Several physical functions require the synthesis of steroid hormones, in which gonadal steroids (estrogen and progesterone) play a pivotal role in reproduction. Follicular growth and ovulation depend on the proliferation and differentiation of the granulosa and theca cells, which are possible in the steroid pathway after stimulation with the ovarian gonadotropins and cytokines. Steroidization is initiated with the transfer of cholesterol by the StAR protein to the mitochondrial membrane of the steroid cells, which is followed by a cascade of steroid hormones. Recent studies have highlighted the impact of epigenetic mechanisms on reproduction, emphasizing the importance of these changes in the early and secondary stages of gametogenesis. To determine the causes of infertility, it is essential to recognize the altered epigenetic modifications of the relevant gene and its mechanisms. In the present study, the H3K4me3 methylation level was evaluated in the StAR gene regulatory region in the granulosa cells collected from the fertile and infertile women referring to Tabriz Jihad Infertility Centerin Tabriz, Iran using ChIP-qPCR. According to the results, the H3K4me3 methylation level increased in the StAR gene regulatory region in the fertile women compared to the infertile women. In addition, a significant correlation was observed between the follicle and egg rates at the MII stage and the level of this methylation.

Page 1 from 1     

© 2025 CC BY-NC 4.0 | Jorjani Biomedicine Journal

Designed & Developed by : Yektaweb