Jorjani Biomedicine Journal

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Methods: This research had an A-B single-subject design. The research population encompassed all patients with coronary heart disease referring to Shahid Madani Hospital of Tabriz, Iran during the second half of 2016 for rehabilitation measures. Four patients were selected using convenience sampling. Before the interventions, the participants completed state-trait anger expression inventory (STAXI-2, Spielberger) and depression anxiety stress scale (DASS) throughout two consecutive weeks, which led to establishing two baselines. Afterwards, they received mindfulness-based stress reduction training during seven consecutive weeks and completed the questionnaires after each intervention. Percentage of recovery, percentage of non-overlapping data (PND), standard mean difference (SMD), and effect size were used to analyze the data, and eye diagram analysis was adopted to interpret the data.
Results: The findings indicated that the mean recovery rate for all participants was 0.84 and its effect size index was 2.7. Moreover, the mean percentage of recovery and the effect size index of mindfulness intervention on the patients’ anger were 0.18 and 1.38, respectively.
Conclusion: According to the results of the study, it could be concluded that mindfulness-based stress reduction is an effective intervention to regulate stress in patients suffering from coronary heart disease.

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Background and objectives: Elderly is characterized by decreased cardiac function, which is widely associated with mitochondrial failure in cell death. Elderly causes heart apoptosis. Although the old heart is vulnerable to apoptosis, physical training and some supplements through different mechanisms could be effective in reducing apoptosis. The present study aimed to investigate the effect of interval training on some apoptotic parameters of Bax and Bcl2 cardiomyocytes in old female rats.
 
Methods: In an experimental study, 49 Wistar female rats (2 years old) were randomly assigned into 7 groups: control, saline, curcumin, moderate intensity training, moderate intensity training + curcumin, high intensity training, high intensity training + curcumin. The experimental groups received gavage doses of curcumin 30 mg / kg body weight three days a week via. The saline group also received the same amount of saline. Training groups had moderate and severe exercises on the treadmill for eight weeks, and three sessions per week. Forty-eight hours after the last training session and gavage, the animals were killed and their heart tissues were isolated to determine the levels of Bax and Bcl2.
 
Results: The results indicated that interval training and curcumin consumption could significantly increase the levels of Bcl2 and BAX and the BAX / Bcl2 ratio, the amount of which depends on the intensity of training. Moreover, the combination of training and curcumin had an antagonistic effect.
 
Conclusion: According to the results, physical activity and curcumin separately have a protective effect on the heart tissue; however, these two interventions do not enhance each other’s effect. Hence each one is suggested to be used separately.