Mehdi Dehghani Kazemi, Zahra Ebrahimnezhad, Hamid Beyzaei,
Volume 11, Issue 2 (10-2023)
Abstract
Background: Anabasis setifera and Caroxylon imbricatum are two halophytic and xerophytic plant species belonging to the family Chenopoodiaceae s.str., that are distributed widely in dry environments of the Old World. This study investigated the antioxidant and antibacterial properties of the hydroethanolic extracts of fruit-bearing branches of these species collected from Zabol in the east of Iran.
Methods: The antimicrobial effect was essayed using broth microdilution and streak plate protocols against nine pathogenic microorganisms from different genera, including Klebsiella, Pseudomonas, Escherichia, Bacillus, Staphylococcus, Streptococcus, Aspergillus, Fusarium and Candida. The antioxidant activity was measured by the DPPH free radical scavenging method.
Results: Extracts were effective on all tested bacterial and fungal strains except for Candida albicans, which Caroxylon imbricatum didn’t affect. The MIC values ranged from 8 to 2048 μg/ml. The IC50 values of 76.40 and 154.05 μg/ml were observed with Anabasis setifera and Caroxylon imbricatum extracts, respectively.
Conclusion: These plant species can efficiently treat infectious and oxidative stress-related diseases due to their broad spectrum antimicrobial properties and acceptable antioxidant activities.
Azar Mohammadi, Abdolhossein Taheri Kalani, Mahnaz Omidi,
Volume 12, Issue 1 (10-2024)
Abstract
Background: When metabolic demands increase due to an obesity-induced high-fat diet (HFD), mitochondrial function is impaired, production can increase, and oxidative stress occurs. This type of stress has been shown to play a key role in various pathological conditions such as heart disease, hypertension, diabetes, chronic kidney disease, and cancers. This study aims to evaluate the impact of HFD and resistance training (RT) on oxidative stress biomarkers and cardiac health in rats.
Methods: In this experimental study, 21 male Wistar rats (weighing 200-300 g) were randomly and equally assigned into the following groups: control (CTRL), HFD, and HFD+ RT. Animals in the HFD groups received a high-fat diet for 23 weeks. During the treatments, rats in the HFD+ RT group, besides receiving a high-fat diet, performed the progressive RT protocol three times per week with 30- 100% of their body mass in the last eight weeks. At the end of the treatments, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels in cardiac tissue were measured by colorimetric method. The data were analyzed by one-way analysis of variance (ANOVA) and Tukey’s post hoc test at a significant level of P<0.05.
Results: HFD did not alter levels of SOD, GPX, TAC, or MDA in cardiac tissue. Cardiac SOD (P=0.021), GPX (P=0.024), and TAC (P=0.041) levels in the HFD+ RT increased significantly compared to the HFD group, but there was no significant difference in cardiac MDA levels between the three groups (P=0.438).
Conclusion: RT seems to improve cardiac tissue oxidative stress adaptations in an animal model fed with an HFD.
